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Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.

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Title: Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.
Authors: Park SJ; Department of Physiology, Jeonbuk National University Medical School, Jeonju, Republic of Korea., Lee SW; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea., Moon H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea., Jung SM; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea., Kim JM; Department of Pathology, Konyang University College of Medicine, Daejeon, Republic of Korea., Lee DS; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr., Choi EH; Department of Biotechnology, Korea National University of Transportation, Chungbuk, Republic of Korea. ehchoi@ut.ac.kr.
Source: Oncogene [Oncogene] 2026 Aug; Vol. 45 (29), pp. 2914-2931. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5594
DOI:10.1038/s41388-026-03850-5