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ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness.

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Title: ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness.
Authors: Zaccaria A; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Cascini C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Ratti C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Botti L; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Pernici D; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Cancila V; Department of Health Sciences, Tumor Immunology Unit, University of Palermo School of Medicine, Palermo, 90134, Italy., Armiraglio E; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy., Parafioriti A; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy., Meazza C; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy., Sangaletti S; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Tripodo C; Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, 20139, Italy., Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Colombo MP; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Lecis D; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Chiodoni C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy. claudia.chiodoni@istitutotumori.mi.it.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1756-9966
DOI:10.1186/s13046-026-03757-9