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ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness.

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Title: ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness.
Authors: Zaccaria A; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Cascini C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Ratti C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Botti L; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Pernici D; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Cancila V; Department of Health Sciences, Tumor Immunology Unit, University of Palermo School of Medicine, Palermo, 90134, Italy., Armiraglio E; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy., Parafioriti A; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy., Meazza C; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy., Sangaletti S; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Tripodo C; Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, 20139, Italy., Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy., Colombo MP; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Lecis D; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy., Chiodoni C; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy. claudia.chiodoni@istitutotumori.mi.it.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness.
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  Data: <searchLink fieldCode="AU" term="%22Zaccaria+A%22">Zaccaria A</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Cascini+C%22">Cascini C</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Ratti+C%22">Ratti C</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Botti+L%22">Botti L</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Pernici+D%22">Pernici D</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Cancila+V%22">Cancila V</searchLink>; Department of Health Sciences, Tumor Immunology Unit, University of Palermo School of Medicine, Palermo, 90134, Italy.<br /><searchLink fieldCode="AU" term="%22Armiraglio+E%22">Armiraglio E</searchLink>; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Parafioriti+A%22">Parafioriti A</searchLink>; Department of Pathology, Istituto Ortopedico Gaetano Pini, Milan, 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Meazza+C%22">Meazza C</searchLink>; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Sangaletti+S%22">Sangaletti S</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Tripodo+C%22">Tripodo C</searchLink>; Advanced Pathology Laboratory, IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, 20139, Italy.<br /><searchLink fieldCode="AU" term="%22Scotlandi+K%22">Scotlandi K</searchLink>; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, 40136, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+MP%22">Colombo MP</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Lecis+D%22">Lecis D</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Chiodoni+C%22">Chiodoni C</searchLink>; Department of Experimental Oncology, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy. claudia.chiodoni@istitutotumori.mi.it.
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              Text: 2026 Jun 15
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