ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations.
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| Title: | ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations. |
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| Authors: | Sabino LR; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, 2308, Australia.; Immune Health Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia., Kaiko GE; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, 2308, Australia.; Immune Health Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia., Dorahy D; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia., Goodsall T; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Gastroenterology, John Hunter Hospital, Newcastle, NSW, 2305, Australia., Jaffe A; Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW, Sydney, Australia.; Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW, Australia., Schultz A; Wal-Yan Respiratory Research Centre, The Kids Research Institute, University of Western Australia, Perth, Australia.; Department of Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, Australia., Waters S; Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Cook D; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Gastroenterology, John Hunter Hospital, Newcastle, NSW, 2305, Australia., Kok H; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.; Asthma and Breathing Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia., Tong K; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.; Asthma and Breathing Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia., Totterdell J; Sydney School of Public Health, The University of Sydney, Sydney, NSW, 2006, Australia., McGree J; School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD, 4000, Australia., Snelling T; Sydney School of Public Health, The University of Sydney, Sydney, NSW, 2006, Australia., Wark PAB; Department of Respiratory Medicine, Alfred Health, Melbourne, VIC, 3181, Australia. P.Wark@alfred.org.au.; School of Translational Medicine, Monash University, Melbourne, Australia. P.Wark@alfred.org.au. |
| Source: | Trials [Trials] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42298697 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sabino+LR%22">Sabino LR</searchLink>; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, 2308, Australia.; Immune Health Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Kaiko+GE%22">Kaiko GE</searchLink>; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, 2308, Australia.; Immune Health Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Dorahy+D%22">Dorahy D</searchLink>; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.<br /><searchLink fieldCode="AU" term="%22Goodsall+T%22">Goodsall T</searchLink>; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Gastroenterology, John Hunter Hospital, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Jaffe+A%22">Jaffe A</searchLink>; Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW, Sydney, Australia.; Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Schultz+A%22">Schultz A</searchLink>; Wal-Yan Respiratory Research Centre, The Kids Research Institute, University of Western Australia, Perth, Australia.; Department of Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Waters+S%22">Waters S</searchLink>; Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW, Australia.; School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cook+D%22">Cook D</searchLink>; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Gastroenterology, John Hunter Hospital, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Kok+H%22">Kok H</searchLink>; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.; Asthma and Breathing Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Tong+K%22">Tong K</searchLink>; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia.; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.; Asthma and Breathing Program, Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia.<br /><searchLink fieldCode="AU" term="%22Totterdell+J%22">Totterdell J</searchLink>; Sydney School of Public Health, The University of Sydney, Sydney, NSW, 2006, Australia.<br /><searchLink fieldCode="AU" term="%22McGree+J%22">McGree J</searchLink>; School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD, 4000, Australia.<br /><searchLink fieldCode="AU" term="%22Snelling+T%22">Snelling T</searchLink>; Sydney School of Public Health, The University of Sydney, Sydney, NSW, 2006, Australia.<br /><searchLink fieldCode="AU" term="%22Wark+PAB%22">Wark PAB</searchLink>; Department of Respiratory Medicine, Alfred Health, Melbourne, VIC, 3181, Australia. P.Wark@alfred.org.au.; School of Translational Medicine, Monash University, Melbourne, Australia. P.Wark@alfred.org.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Jun 15. <i>Date of Electronic Publication: </i>2026 Jun 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42298697 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13063-026-09789-y Languages: – Code: eng Text: English Titles: – TitleFull: ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sabino LR – PersonEntity: Name: NameFull: Kaiko GE – PersonEntity: Name: NameFull: Dorahy D – PersonEntity: Name: NameFull: Goodsall T – PersonEntity: Name: NameFull: Jaffe A – PersonEntity: Name: NameFull: Schultz A – PersonEntity: Name: NameFull: Waters S – PersonEntity: Name: NameFull: Cook D – PersonEntity: Name: NameFull: Kok H – PersonEntity: Name: NameFull: Tong K – PersonEntity: Name: NameFull: Totterdell J – PersonEntity: Name: NameFull: McGree J – PersonEntity: Name: NameFull: Snelling T – PersonEntity: Name: NameFull: Wark PAB IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: 2026 Jun 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1745-6215 Titles: – TitleFull: Trials Type: main |
| ResultId | 1 |
