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CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination.

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Title: CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination.
Authors: Li L; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Shi Y; Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing, China., Luo Q; Department of Ultrasound, Chonggang General Hospital, Chongqing University of Posts and Telecommunications, Chongqing, China., Guo P; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Jin T; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Ru X; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Jiang Z; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Niu Y; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Li W; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Chen Y; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Chen Z; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Jun; Vol. 32 (6), pp. e70984.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
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  Data: CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination.
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  Data: <searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Luo+Q%22">Luo Q</searchLink>; Department of Ultrasound, Chonggang General Hospital, Chongqing University of Posts and Telecommunications, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Guo+P%22">Guo P</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jin+T%22">Jin T</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Ru+X%22">Ru X</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Niu+Y%22">Niu Y</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
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        Value: 10.1002/cns.70984
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      – TitleFull: CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination.
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              Text: 2026 Jun
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