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Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.

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Bibliographic Details
Title: Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.
Authors: Wilbie D; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Timmers M; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Kogkalidou A; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Hebels ER; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Sweet IR; Division of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3508 TB, The Netherlands., Maas-Bakker R; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Bosman E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., de Jong OG; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Vermonden T; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Mastrobattista E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Jun 23; Vol. 62 (48), pp. 12084-12088. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1364-548X
DOI:10.1039/d6cc01443g