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Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.

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Title: Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.
Authors: Wilbie D; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Timmers M; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Kogkalidou A; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Hebels ER; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Sweet IR; Division of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3508 TB, The Netherlands., Maas-Bakker R; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Bosman E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., de Jong OG; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Vermonden T; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Mastrobattista E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Jun 23; Vol. 62 (48), pp. 12084-12088. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Wilbie+D%22">Wilbie D</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22Timmers+M%22">Timmers M</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kogkalidou+A%22">Kogkalidou A</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22Hebels+ER%22">Hebels ER</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sweet+IR%22">Sweet IR</searchLink>; Division of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3508 TB, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maas-Bakker+R%22">Maas-Bakker R</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22Bosman+E%22">Bosman E</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22de+Jong+OG%22">de Jong OG</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22Vermonden+T%22">Vermonden T</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.<br /><searchLink fieldCode="AU" term="%22Mastrobattista+E%22">Mastrobattista E</searchLink>; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.
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  Data: <searchLink fieldCode="JN" term="%229610838%22">Chemical communications (Cambridge, England)</searchLink> [Chem Commun (Camb)] 2026 Jun 23; Vol. 62 (48), pp. 12084-12088. <i>Date of Electronic Publication: </i>2026 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9610838 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1364-548X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213597345%22">13597345 </searchLink><i>NLM ISO Abbreviation: </i>Chem Commun (Camb) <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 23
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