Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.
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| Title: | Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates. |
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| Authors: | Wilbie D; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Timmers M; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Kogkalidou A; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Hebels ER; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl.; Cristal Therapeutics, Maastricht 6229 EV, The Netherlands., Sweet IR; Division of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3508 TB, The Netherlands., Maas-Bakker R; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Bosman E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., de Jong OG; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Vermonden T; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl., Mastrobattista E; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands. e.mastrobattista@uu.nl. |
| Source: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 Jun 23; Vol. 62 (48), pp. 12084-12088. Date of Electronic Publication: 2026 Jun 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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