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Design, synthesis, and evaluation of trisubstituted bicyclo[2.2.2]oct-2-enes as non-classical isosteres of trisubstituted benzenes.

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Title: Design, synthesis, and evaluation of trisubstituted bicyclo[2.2.2]oct-2-enes as non-classical isosteres of trisubstituted benzenes.
Authors: Hsu CW; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw., Liu WQ; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw., Shih FJ; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw., Jheng YJ; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw., Chou CH; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw., Wang YM; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw., Chen SF; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw., Chu J; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.; Center for Emerging Materials and Advanced Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan., Yoo WJ; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.; Center for Emerging Materials and Advanced Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Source: Organic & biomolecular chemistry [Org Biomol Chem] 2026 Jul 08; Vol. 24 (26), pp. 5488-5493. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis, and evaluation of trisubstituted bicyclo[2.2.2]oct-2-enes as non-classical isosteres of trisubstituted benzenes.
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  Data: <searchLink fieldCode="AU" term="%22Hsu+CW%22">Hsu CW</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Liu+WQ%22">Liu WQ</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Shih+FJ%22">Shih FJ</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Jheng+YJ%22">Jheng YJ</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chou+CH%22">Chou CH</searchLink>; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Wang+YM%22">Wang YM</searchLink>; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+SF%22">Chen SF</searchLink>; Department of Chemistry, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Road, Taipei 11677, Taiwan. sfchen@ntnu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chu+J%22">Chu J</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.; Center for Emerging Materials and Advanced Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yoo+WJ%22">Yoo WJ</searchLink>; Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. woojinyoo@ntu.edu.tw.; Center for Emerging Materials and Advanced Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101154995%22">Organic & biomolecular chemistry</searchLink> [Org Biomol Chem] 2026 Jul 08; Vol. 24 (26), pp. 5488-5493. <i>Date of Electronic Publication: </i>2026 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101154995 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214770520%22">14770520 </searchLink><i>NLM ISO Abbreviation: </i>Org Biomol Chem <i>Subsets: </i>MEDLINE; PubMed not MEDLINE
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        Value: 10.1039/d6ob00798h
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        Text: English
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            – D: 08
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              Text: 2026 Jul 08
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              Y: 2026
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