Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.
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| Title: | Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial. |
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| Authors: | Rozemeijer S; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl.; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl., Dubois EA; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Cardiology, Cardiovascular Institute, Rotterdam, The Netherlands., de Grooth HJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.; Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands., den Uil CA; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, Maasstad Hospital, Rotterdam, The Netherlands., Rettig TCD; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands., Rijpstra TA; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands., van den Bogaard B; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., van Zanten ARH; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.; Division of Human Nutrition and Health, Wageningen University & Research, HELIX (Building 124), Wageningen, The Netherlands., Bosman RJ; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., Elbers PWG; Department of Intensive Care Medicine, Amsterdam Medical Data Science (AMDS), Amsterdam Public Health (APH), Amsterdam Cardiovascular Science (ACS), Amsterdam Institute for Infection and Immunity (AI&I), Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands., Girbes ARJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Vlaar APJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Twisk JWR; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands., Christopher KB; Division of Renal Medicine, Brigham and Women's Hospital, Boston, USA., Schober P; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Oudemans-van Straaten HM; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., de Man AME; Department of Intensive Care Medicine, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. ame.deman@amsterdamumc.nl. |
| Source: | Intensive care medicine [Intensive Care Med] 2026 Jul; Vol. 52 (7), pp. 1447-1457. Date of Electronic Publication: 2026 Jun 16. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II |
| Journal Info: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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