AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay.

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Title: AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay.
Authors: Yang T; Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Zhang J; Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhao Z; Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Cheng S; College of Life Sciences, Northwest University, Xi'an, China., Yan Z; Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Wang W; College of Life Sciences, Northwest University, Xi'an, China., Wang G; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China., Zhang R; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, China., Zhang Z; Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Yuan P; Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Zheng X; Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Zhang H; Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. zhhxtdjr@163.com., Li J; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China. lijibin2006@163.com., Xing J; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China. xingjl@fmmu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 16; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-026-02733-1