Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients.
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| Title: | Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients. |
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| Authors: | Manchala A; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Varypataki EM; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Charo J; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Umaña P; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Klein C; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Department of Biochemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University of Munich, Munich, Germany., Codarri Deak L; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Jun 01; Vol. 17, pp. 1843841. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1843841 |
