Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients.
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| Title: | Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients. |
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| Authors: | Manchala A; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Varypataki EM; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Charo J; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Umaña P; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland., Klein C; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Department of Biochemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University of Munich, Munich, Germany., Codarri Deak L; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Jun 01; Vol. 17, pp. 1843841. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42305548 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Target receptor expression dictates the selective intra-tumoral targeting of CD8<superscript>+</superscript> T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Manchala+A%22">Manchala A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Varypataki+EM%22">Varypataki EM</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Charo+J%22">Charo J</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Umaña+P%22">Umaña P</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland.; Department of Biochemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Codarri+Deak+L%22">Codarri Deak L</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jun 01; Vol. 17, pp. 1843841. <i>Date of Electronic Publication: </i>2026 Jun 01 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42305548 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fimmu.2026.1843841 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1843841 Titles: – TitleFull: Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Manchala A – PersonEntity: Name: NameFull: Varypataki EM – PersonEntity: Name: NameFull: Charo J – PersonEntity: Name: NameFull: Umaña P – PersonEntity: Name: NameFull: Klein C – PersonEntity: Name: NameFull: Codarri Deak L IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1664-3224 Numbering: – Type: volume Value: 17 Titles: – TitleFull: Frontiers in immunology Type: main |
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