A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models.

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Bibliographic Details
Title: A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models.
Authors: Zuffa S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Allaband C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Charron-Lamoureux V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Caraballo-Rodriguez AM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Patan A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Mohanty I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Agongo J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Bostick JW; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Connerly TJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA., Thron T; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Needam BD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., de Castro Fonseca M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Benitez RS; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hansen L; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Tubb H; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Cao J; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Kalecký K; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., MahmoudianDehkordi S; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Schimmel L; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Kueider-Paisley A; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Graham SF; Metabolomics Department, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA; Oakland University-William Beaumont School of Medicine, Rochester, MI, USA., Siegel D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Wang M; Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA, USA., Knight R; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA, USA; Hong Kong University of Science and Technology Jockey Club Institute for Advanced Study, Hong Kong University of Science and Technology, Hong Kong SAR, China., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address: rima.kaddurahdaouk@duke.edu., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA. Electronic address: pdorrestein@health.ucsd.edu., Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: sarkis@caltech.edu.
Corporate Authors: Alzheimer Gut Microbiome Project Consortium
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117499. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117499