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A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models.

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Title: A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models.
Authors: Zuffa S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Allaband C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Charron-Lamoureux V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Caraballo-Rodriguez AM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Patan A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Mohanty I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Agongo J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Bostick JW; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Connerly TJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA., Thron T; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Needam BD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., de Castro Fonseca M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Benitez RS; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hansen L; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Tubb H; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Cao J; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Kalecký K; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., MahmoudianDehkordi S; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Schimmel L; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Kueider-Paisley A; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Graham SF; Metabolomics Department, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA; Oakland University-William Beaumont School of Medicine, Rochester, MI, USA., Siegel D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Wang M; Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA, USA., Knight R; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA, USA; Hong Kong University of Science and Technology Jockey Club Institute for Advanced Study, Hong Kong University of Science and Technology, Hong Kong SAR, China., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address: rima.kaddurahdaouk@duke.edu., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA. Electronic address: pdorrestein@health.ucsd.edu., Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: sarkis@caltech.edu.
Corporate Authors: Alzheimer Gut Microbiome Project Consortium
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117499. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Zuffa+S%22">Zuffa S</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Allaband+C%22">Allaband C</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Charron-Lamoureux+V%22">Charron-Lamoureux V</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Caraballo-Rodriguez+AM%22">Caraballo-Rodriguez AM</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Patan+A%22">Patan A</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mohanty+I%22">Mohanty I</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Agongo+J%22">Agongo J</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bostick+JW%22">Bostick JW</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Connerly+TJ%22">Connerly TJ</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Thron+T%22">Thron T</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Needam+BD%22">Needam BD</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22de+Castro+Fonseca+M%22">de Castro Fonseca M</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Benitez+RS%22">Benitez RS</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+L%22">Hansen L</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tubb+H%22">Tubb H</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kalecký+K%22">Kalecký K</searchLink>; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bottiglieri+T%22">Bottiglieri T</searchLink>; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22MahmoudianDehkordi+S%22">MahmoudianDehkordi S</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Schimmel+L%22">Schimmel L</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kueider-Paisley+A%22">Kueider-Paisley A</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Graham+SF%22">Graham SF</searchLink>; Metabolomics Department, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA; Oakland University-William Beaumont School of Medicine, Rochester, MI, USA.<br /><searchLink fieldCode="AU" term="%22Siegel+D%22">Siegel D</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA, USA.<br /><searchLink fieldCode="AU" term="%22Knight+R%22">Knight R</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA, USA; Hong Kong University of Science and Technology Jockey Club Institute for Advanced Study, Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Kaddurah-Daouk+R%22">Kaddurah-Daouk R</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address: rima.kaddurahdaouk@duke.edu.<br /><searchLink fieldCode="AU" term="%22Dorrestein+PC%22">Dorrestein PC</searchLink>; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA. Electronic address: pdorrestein@health.ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Mazmanian+SK%22">Mazmanian SK</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: sarkis@caltech.edu.
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