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Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.

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Title: Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.
Authors: Wekerle T; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Muckenhuber M; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Heinzel A; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Weijler AM; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., David AF; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Kainz V; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Hu K; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Mucha J; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Mengrelis K; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Reindl-Schwaighofer R; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Böhmig GA; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Watschinger B; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Györi G; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Soliman T; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Salat A; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Schwarz C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Muhm M; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Heinze G; Institute of Clinical Biometrics, Center for Medical Data Science, Informatics, and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria., Wolzt M; Clinical Trials Coordination Centre, Medical University of Vienna, 1090 Vienna, Austria., Worel N; Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, 1090 Vienna, Austria., Fortschegger M; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Lion T; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Regele H; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Berlakovich G; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Halloran PF; Division of Nephrology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada., Edinger M; University Hospital Regensburg, Department of Internal Medicine III, José Carreras Centrum for Somatic Cell Therapy, Leibniz Institute of Immunotherapy, 93053 Regensburg, Germany., Oberbauer R; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eaee6850. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aee6850