Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections.
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| Title: | Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections. |
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| Authors: | Ali YM; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Yabuki M; Omeros Corporation, Seattle, WA 98119, USA., Arachchilage CH; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Khatri P; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Lynch NJ; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Bruchmann S; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK., Weimann A; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK., Brown K; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK., Floto RA; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK., Parkhill J; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Petraitis V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Petraitiene R; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Walsh TJ; Departments of Medicine and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Center for Innovative Therapeutics and Diagnostics, Richmond, VA 23220, USA., Briles DE; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA., MacDaniel LS; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA.; Center for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA., Utsugi H; Omeros Corporation, Seattle, WA 98119, USA., Gragerova G; Omeros Corporation, Seattle, WA 98119, USA., Misquith A; Omeros Corporation, Seattle, WA 98119, USA., Doulami C; Omeros Corporation, Seattle, WA 98119, USA., Demopulos G; Omeros Corporation, Seattle, WA 98119, USA., Schwaeble W; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eadx4108. Date of Electronic Publication: 2026 Jun 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adx4108 |
