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Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections.

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Title: Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections.
Authors: Ali YM; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Yabuki M; Omeros Corporation, Seattle, WA 98119, USA., Arachchilage CH; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Khatri P; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Lynch NJ; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Bruchmann S; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK., Weimann A; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK., Brown K; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK., Floto RA; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK., Parkhill J; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK., Petraitis V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Petraitiene R; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Walsh TJ; Departments of Medicine and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Center for Innovative Therapeutics and Diagnostics, Richmond, VA 23220, USA., Briles DE; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA., MacDaniel LS; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA.; Center for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA., Utsugi H; Omeros Corporation, Seattle, WA 98119, USA., Gragerova G; Omeros Corporation, Seattle, WA 98119, USA., Misquith A; Omeros Corporation, Seattle, WA 98119, USA., Doulami C; Omeros Corporation, Seattle, WA 98119, USA., Demopulos G; Omeros Corporation, Seattle, WA 98119, USA., Schwaeble W; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eadx4108. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections.
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  Data: <searchLink fieldCode="AU" term="%22Ali+YM%22">Ali YM</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Yabuki+M%22">Yabuki M</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Arachchilage+CH%22">Arachchilage CH</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Khatri+P%22">Khatri P</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Lynch+NJ%22">Lynch NJ</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Bruchmann+S%22">Bruchmann S</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.<br /><searchLink fieldCode="AU" term="%22Weimann+A%22">Weimann A</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.<br /><searchLink fieldCode="AU" term="%22Brown+K%22">Brown K</searchLink>; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK.<br /><searchLink fieldCode="AU" term="%22Floto+RA%22">Floto RA</searchLink>; Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK.<br /><searchLink fieldCode="AU" term="%22Parkhill+J%22">Parkhill J</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Petraitis+V%22">Petraitis V</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.<br /><searchLink fieldCode="AU" term="%22Petraitiene+R%22">Petraitiene R</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+TJ%22">Walsh TJ</searchLink>; Departments of Medicine and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Center for Innovative Therapeutics and Diagnostics, Richmond, VA 23220, USA.<br /><searchLink fieldCode="AU" term="%22Briles+DE%22">Briles DE</searchLink>; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA.<br /><searchLink fieldCode="AU" term="%22MacDaniel+LS%22">MacDaniel LS</searchLink>; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35209, USA.; Center for Immunology and Microbial Research, Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.<br /><searchLink fieldCode="AU" term="%22Utsugi+H%22">Utsugi H</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Gragerova+G%22">Gragerova G</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Misquith+A%22">Misquith A</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Doulami+C%22">Doulami C</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Demopulos+G%22">Demopulos G</searchLink>; Omeros Corporation, Seattle, WA 98119, USA.<br /><searchLink fieldCode="AU" term="%22Schwaeble+W%22">Schwaeble W</searchLink>; Department of Veterinary Medicine, School of Biological Sciences, University of Cambridge, Cambridge CB3 0ES, UK.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eadx4108. <i>Date of Electronic Publication: </i>2026 Jun 17.
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