Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons.

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Title: Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons.
Authors: Diaz Escarcega R; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., M J VK; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., Arizmendez A; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., Tan C; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., Urayama A; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., Marrelli SP; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA., Morales R; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Centro Integrativo de Biologia y Quimica Aplicada (CIBQA), Universidad Bernardo O'Higgins, Santiago, Chile., Wefel JS; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang C; Department of Otorhinolaryngology, Head and Neck Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA., McCullough LD; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA.; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA., Kim N; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA., Monchaud D; Institut De Chimie Moléculaire de l'Université de Bourgogne (ICMUB), Université Bourgogne Europe (UBE), Dijon, France., Jung SY; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Tsvetkov AS; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. andrey.s.tsvetkov@uth.tmc.edu.; The BRAINS Research Laboratory, the Department of Neurology, University of Texas McGovern Medical School, Houston, TX, USA. andrey.s.tsvetkov@uth.tmc.edu.; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA. andrey.s.tsvetkov@uth.tmc.edu.
Source: Cell death & disease [Cell Death Dis] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08971-z