Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource.
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| Title: | Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource. |
|---|---|
| Authors: | Koch C; Biomedical Research at Novartis, Cambridge, MA, USA. christopher-1.koch@novartis.com., Khalid S; Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Khan MZ; Center for Non-Communicable Diseases, Karachi, Pakistan., Bandyadka S; Biomedical Research at Novartis, Cambridge, MA, USA., Doyon B; Biomedical Research at Novartis, Cambridge, MA, USA., Denning DP; Biomedical Research at Novartis, Cambridge, MA, USA., Jahanzaib M; Center for Non-Communicable Diseases, Karachi, Pakistan., Mian MR; Center for Non-Communicable Diseases, Karachi, Pakistan., Gul W; Center for Non-Communicable Diseases, Karachi, Pakistan., Liaqat MB; Center for Non-Communicable Diseases, Karachi, Pakistan., Bano A; Center for Non-Communicable Diseases, Karachi, Pakistan., Dahar M; Center for Non-Communicable Diseases, Karachi, Pakistan., Saqib N; Center for Non-Communicable Diseases, Karachi, Pakistan., Kamani L; Department of Gastroenterology, Liaquat National Hospital, Karachi, Pakistan., Butt N; Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan., Jalal A; Punjab Institute of Cardiology, Lahore, Pakistan., Sultana R; Karachi Institute of Heart Diseases, Karachi, Pakistan., Abbas S; Faisalabad Institute of Cardiology, Faisalabad, Pakistan., Siddiqeh M; Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan., Haroon M; Department of Rheumatology, Fatima Memorial Hospital and FMH College of Medicine and Dentistry, Lahore, Pakistan., Khan A; Department of Rheumatology, Bolan Medical Complex Hospital, Quetta, Pakistan., Babar KP; Department of Rheumatology, Madinah Teaching Hospital, University Medical and Dental College, Faisalabad, Pakistan., Rasheed A; Department of Rheumatology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Iqbal J; Department of Neurology, Allied Hospital, Faisalabad, Pakistan., Aslam F; Department of Neurology, Aziz Fatima Hospital, Faisalabad, Pakistan., Usman U; Department of Pulmonology, Allied Hospital, Faisalabad, Pakistan., Bajwa MA; Department of Gastroenterology, Civil Hospital, Hyderabad and Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Hyder A; Department of Gastroenterology, Civil Hospital, Larkana and Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan., Memon MS; Asian Institute of Medical Sciences, Hyderabad, Pakistan., Hashmani N; Hashmanis Group of Hospitals, Karachi, Pakistan., Haroon MI; Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad, Pakistan., Muddassir A; Department of Medicine, Shaikh Zayed Medical Complex, Lahore, Pakistan., Zaidi SAR; Department of Gastroenterology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Akram M; Department of Nephrology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Hussain M; Department of Pulmonology, Services Institute of Medical Sciences, Lahore, Pakistan., Mohsin SN; NHRC, Shaikh Zayed Medical Complex, Lahore, Pakistan., Bugti S; Department of Medicine, Bolan Medical Complex Hospital, Quetta, Pakistan., Mehmood T; Department of Medicine, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan., Rodeni AL; Department of Gastroenterology, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan., Mukhtar S; Department of Medicine, Lahore General Hospital, Lahore, Pakistan., Rasool T; Akhuwat Health Services, Lahore, Pakistan., Mahmood A; Department of Medicine, Bahawal Victoria Hospital, Bahawalpur, Pakistan., Wazir MN; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan., Khan SJ; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan., Khan MA; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan., Ghaffar R; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan., Jan S; Pakistan Institute of Community Ophthalmology, Hayatabad Medical Complex, Peshawar, Pakistan., Ul Hadi N; Department of Cardiology, Mardan Medical Complex, Mardan, Pakistan., Anjum R; Department of Nephrology, Lahore General Hospital, Lahore, Pakistan., Abdullah R; Institute of Nuclear Medicine and Oncology, Lahore, Pakistan., Musharraf MU; Department of Medicine, Allied Hospital, Faisalabad, Pakistan., Bashir MT; Department of Oncology, Allied Hospital, Faisalabad, Pakistan., Ali M; THQ Hospital, Jaranwala, Punjab, Pakistan., Majeed I; Afzal Heart Center, Allama Iqbal Memorial Teaching Hospital and Khawaja Muhammad Safdar Medical College, Sialkot, Pakistan., Bilal MH; Department of Medicine, Alama Iqbal Teaching Hospital and DG Khan Medical College, Dera Ghazi Khan, Pakistan., Khan SA; Health Services Academy, Islamabad, Pakistan., Hata C; Astellas Pharma, Ibaraki, Japan., Kou I; Astellas Pharma, Ibaraki, Japan., Asaumi M; Astellas Pharma, Ibaraki, Japan., Morii W; Astellas Pharma, Ibaraki, Japan., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Kundu K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lythgow K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., MacArthur S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wasilewski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rodriguez-Flores JL; Weill Cornell Medicine, New York, NY, USA.; Regeneron Genetics Center, Tarrytown, NY, USA., Riaz M; Regeneron Genetics Center, Tarrytown, NY, USA., Kapoor M; Regeneron Genetics Center, Tarrytown, NY, USA., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Shuldiner AR; Regeneron Genetics Center, Tarrytown, NY, USA., Bradner JE; Amgen, Thousand Oaks, CA, USA., Splawski I; Yarrow Biotechnology, New York, NY, USA., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Dominy JE; Biomedical Research at Novartis, Cambridge, MA, USA. john.e.dominy@outlook.com., Gurtan AM; Biomedical Research at Novartis, Cambridge, MA, USA. allan.gurtan@outlook.com., Saleheen D; Columbia University Irving Medical Center, New York, NY, USA. ds3792@cumc.columbia.edu.; Center for Non-Communicable Diseases, Karachi, Pakistan. ds3792@cumc.columbia.edu. |
| Corporate Authors: | Regeneron Genetics Center |
| Source: | Nature [Nature] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42310464 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Koch+C%22">Koch C</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA. christopher-1.koch@novartis.com.<br /><searchLink fieldCode="AU" term="%22Khalid+S%22">Khalid S</searchLink>; Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+MZ%22">Khan MZ</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bandyadka+S%22">Bandyadka S</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doyon+B%22">Doyon B</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Denning+DP%22">Denning DP</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jahanzaib+M%22">Jahanzaib M</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mian+MR%22">Mian MR</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Gul+W%22">Gul W</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Liaqat+MB%22">Liaqat MB</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bano+A%22">Bano A</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Dahar+M%22">Dahar M</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Saqib+N%22">Saqib N</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Kamani+L%22">Kamani L</searchLink>; Department of Gastroenterology, Liaquat National Hospital, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Butt+N%22">Butt N</searchLink>; Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Jalal+A%22">Jalal A</searchLink>; Punjab Institute of Cardiology, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Sultana+R%22">Sultana R</searchLink>; Karachi Institute of Heart Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Abbas+S%22">Abbas S</searchLink>; Faisalabad Institute of Cardiology, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Siddiqeh+M%22">Siddiqeh M</searchLink>; Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Haroon+M%22">Haroon M</searchLink>; Department of Rheumatology, Fatima Memorial Hospital and FMH College of Medicine and Dentistry, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Department of Rheumatology, Bolan Medical Complex Hospital, Quetta, Pakistan.<br /><searchLink fieldCode="AU" term="%22Babar+KP%22">Babar KP</searchLink>; Department of Rheumatology, Madinah Teaching Hospital, University Medical and Dental College, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rasheed+A%22">Rasheed A</searchLink>; Department of Rheumatology, Shaikh Zayed Medical Complex, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Iqbal+J%22">Iqbal J</searchLink>; Department of Neurology, Allied Hospital, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Aslam+F%22">Aslam F</searchLink>; Department of Neurology, Aziz Fatima Hospital, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Usman+U%22">Usman U</searchLink>; Department of Pulmonology, Allied Hospital, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bajwa+MA%22">Bajwa MA</searchLink>; Department of Gastroenterology, Civil Hospital, Hyderabad and Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hyder+A%22">Hyder A</searchLink>; Department of Gastroenterology, Civil Hospital, Larkana and Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan.<br /><searchLink fieldCode="AU" term="%22Memon+MS%22">Memon MS</searchLink>; Asian Institute of Medical Sciences, Hyderabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hashmani+N%22">Hashmani N</searchLink>; Hashmanis Group of Hospitals, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Haroon+MI%22">Haroon MI</searchLink>; Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Muddassir+A%22">Muddassir A</searchLink>; Department of Medicine, Shaikh Zayed Medical Complex, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Zaidi+SAR%22">Zaidi SAR</searchLink>; Department of Gastroenterology, Shaikh Zayed Medical Complex, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Akram+M%22">Akram M</searchLink>; Department of Nephrology, Shaikh Zayed Medical Complex, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hussain+M%22">Hussain M</searchLink>; Department of Pulmonology, Services Institute of Medical Sciences, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mohsin+SN%22">Mohsin SN</searchLink>; NHRC, Shaikh Zayed Medical Complex, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bugti+S%22">Bugti S</searchLink>; Department of Medicine, Bolan Medical Complex Hospital, Quetta, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mehmood+T%22">Mehmood T</searchLink>; Department of Medicine, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rodeni+AL%22">Rodeni AL</searchLink>; Department of Gastroenterology, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mukhtar+S%22">Mukhtar S</searchLink>; Department of Medicine, Lahore General Hospital, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rasool+T%22">Rasool T</searchLink>; Akhuwat Health Services, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mahmood+A%22">Mahmood A</searchLink>; Department of Medicine, Bahawal Victoria Hospital, Bahawalpur, Pakistan.<br /><searchLink fieldCode="AU" term="%22Wazir+MN%22">Wazir MN</searchLink>; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+SJ%22">Khan SJ</searchLink>; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+MA%22">Khan MA</searchLink>; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ghaffar+R%22">Ghaffar R</searchLink>; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Jan+S%22">Jan S</searchLink>; Pakistan Institute of Community Ophthalmology, Hayatabad Medical Complex, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ul+Hadi+N%22">Ul Hadi N</searchLink>; Department of Cardiology, Mardan Medical Complex, Mardan, Pakistan.<br /><searchLink fieldCode="AU" term="%22Anjum+R%22">Anjum R</searchLink>; Department of Nephrology, Lahore General Hospital, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Abdullah+R%22">Abdullah R</searchLink>; Institute of Nuclear Medicine and Oncology, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Musharraf+MU%22">Musharraf MU</searchLink>; Department of Medicine, Allied Hospital, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bashir+MT%22">Bashir MT</searchLink>; Department of Oncology, Allied Hospital, Faisalabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; THQ Hospital, Jaranwala, Punjab, Pakistan.<br /><searchLink fieldCode="AU" term="%22Majeed+I%22">Majeed I</searchLink>; Afzal Heart Center, Allama Iqbal Memorial Teaching Hospital and Khawaja Muhammad Safdar Medical College, Sialkot, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bilal+MH%22">Bilal MH</searchLink>; Department of Medicine, Alama Iqbal Teaching Hospital and DG Khan Medical College, Dera Ghazi Khan, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+SA%22">Khan SA</searchLink>; Health Services Academy, Islamabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hata+C%22">Hata C</searchLink>; Astellas Pharma, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Kou+I%22">Kou I</searchLink>; Astellas Pharma, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Asaumi+M%22">Asaumi M</searchLink>; Astellas Pharma, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Morii+W%22">Morii W</searchLink>; Astellas Pharma, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Smith+KR%22">Smith KR</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kundu+K%22">Kundu K</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lythgow+K%22">Lythgow K</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22MacArthur+S%22">MacArthur S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wasilewski+S%22">Wasilewski S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Petrovski+S%22">Petrovski S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Flores+JL%22">Rodriguez-Flores JL</searchLink>; Weill Cornell Medicine, New York, NY, USA.; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Riaz+M%22">Riaz M</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kapoor+M%22">Kapoor M</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Backman+JD%22">Backman JD</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shuldiner+AR%22">Shuldiner AR</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bradner+JE%22">Bradner JE</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Splawski+I%22">Splawski I</searchLink>; Yarrow Biotechnology, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rasheed+A%22">Rasheed A</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Dominy+JE%22">Dominy JE</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA. john.e.dominy@outlook.com.<br /><searchLink fieldCode="AU" term="%22Gurtan+AM%22">Gurtan AM</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA. allan.gurtan@outlook.com.<br /><searchLink fieldCode="AU" term="%22Saleheen+D%22">Saleheen D</searchLink>; Columbia University Irving Medical Center, New York, NY, USA. ds3792@cumc.columbia.edu.; Center for Non-Communicable Diseases, Karachi, Pakistan. ds3792@cumc.columbia.edu. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Regeneron+Genetics+Center%22">Regeneron Genetics Center</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jun 17. <i>Date of Electronic Publication: </i>2026 Jun 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42310464 |
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