Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource.

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Title: Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource.
Authors: Koch C; Biomedical Research at Novartis, Cambridge, MA, USA. christopher-1.koch@novartis.com., Khalid S; Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Khan MZ; Center for Non-Communicable Diseases, Karachi, Pakistan., Bandyadka S; Biomedical Research at Novartis, Cambridge, MA, USA., Doyon B; Biomedical Research at Novartis, Cambridge, MA, USA., Denning DP; Biomedical Research at Novartis, Cambridge, MA, USA., Jahanzaib M; Center for Non-Communicable Diseases, Karachi, Pakistan., Mian MR; Center for Non-Communicable Diseases, Karachi, Pakistan., Gul W; Center for Non-Communicable Diseases, Karachi, Pakistan., Liaqat MB; Center for Non-Communicable Diseases, Karachi, Pakistan., Bano A; Center for Non-Communicable Diseases, Karachi, Pakistan., Dahar M; Center for Non-Communicable Diseases, Karachi, Pakistan., Saqib N; Center for Non-Communicable Diseases, Karachi, Pakistan., Kamani L; Department of Gastroenterology, Liaquat National Hospital, Karachi, Pakistan., Butt N; Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan., Jalal A; Punjab Institute of Cardiology, Lahore, Pakistan., Sultana R; Karachi Institute of Heart Diseases, Karachi, Pakistan., Abbas S; Faisalabad Institute of Cardiology, Faisalabad, Pakistan., Siddiqeh M; Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan., Haroon M; Department of Rheumatology, Fatima Memorial Hospital and FMH College of Medicine and Dentistry, Lahore, Pakistan., Khan A; Department of Rheumatology, Bolan Medical Complex Hospital, Quetta, Pakistan., Babar KP; Department of Rheumatology, Madinah Teaching Hospital, University Medical and Dental College, Faisalabad, Pakistan., Rasheed A; Department of Rheumatology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Iqbal J; Department of Neurology, Allied Hospital, Faisalabad, Pakistan., Aslam F; Department of Neurology, Aziz Fatima Hospital, Faisalabad, Pakistan., Usman U; Department of Pulmonology, Allied Hospital, Faisalabad, Pakistan., Bajwa MA; Department of Gastroenterology, Civil Hospital, Hyderabad and Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Hyder A; Department of Gastroenterology, Civil Hospital, Larkana and Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Pakistan., Memon MS; Asian Institute of Medical Sciences, Hyderabad, Pakistan., Hashmani N; Hashmanis Group of Hospitals, Karachi, Pakistan., Haroon MI; Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad, Pakistan., Muddassir A; Department of Medicine, Shaikh Zayed Medical Complex, Lahore, Pakistan., Zaidi SAR; Department of Gastroenterology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Akram M; Department of Nephrology, Shaikh Zayed Medical Complex, Lahore, Pakistan., Hussain M; Department of Pulmonology, Services Institute of Medical Sciences, Lahore, Pakistan., Mohsin SN; NHRC, Shaikh Zayed Medical Complex, Lahore, Pakistan., Bugti S; Department of Medicine, Bolan Medical Complex Hospital, Quetta, Pakistan., Mehmood T; Department of Medicine, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan., Rodeni AL; Department of Gastroenterology, SKBZ Al Nahyan Medical Complex, Quetta, Pakistan., Mukhtar S; Department of Medicine, Lahore General Hospital, Lahore, Pakistan., Rasool T; Akhuwat Health Services, Lahore, Pakistan., Mahmood A; Department of Medicine, Bahawal Victoria Hospital, Bahawalpur, Pakistan., Wazir MN; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan., Khan SJ; Department of Medicine, Hayatabad Medical Complex, Peshawar, Pakistan., Khan MA; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan., Ghaffar R; Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan., Jan S; Pakistan Institute of Community Ophthalmology, Hayatabad Medical Complex, Peshawar, Pakistan., Ul Hadi N; Department of Cardiology, Mardan Medical Complex, Mardan, Pakistan., Anjum R; Department of Nephrology, Lahore General Hospital, Lahore, Pakistan., Abdullah R; Institute of Nuclear Medicine and Oncology, Lahore, Pakistan., Musharraf MU; Department of Medicine, Allied Hospital, Faisalabad, Pakistan., Bashir MT; Department of Oncology, Allied Hospital, Faisalabad, Pakistan., Ali M; THQ Hospital, Jaranwala, Punjab, Pakistan., Majeed I; Afzal Heart Center, Allama Iqbal Memorial Teaching Hospital and Khawaja Muhammad Safdar Medical College, Sialkot, Pakistan., Bilal MH; Department of Medicine, Alama Iqbal Teaching Hospital and DG Khan Medical College, Dera Ghazi Khan, Pakistan., Khan SA; Health Services Academy, Islamabad, Pakistan., Hata C; Astellas Pharma, Ibaraki, Japan., Kou I; Astellas Pharma, Ibaraki, Japan., Asaumi M; Astellas Pharma, Ibaraki, Japan., Morii W; Astellas Pharma, Ibaraki, Japan., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Kundu K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lythgow K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., MacArthur S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wasilewski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rodriguez-Flores JL; Weill Cornell Medicine, New York, NY, USA.; Regeneron Genetics Center, Tarrytown, NY, USA., Riaz M; Regeneron Genetics Center, Tarrytown, NY, USA., Kapoor M; Regeneron Genetics Center, Tarrytown, NY, USA., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Shuldiner AR; Regeneron Genetics Center, Tarrytown, NY, USA., Bradner JE; Amgen, Thousand Oaks, CA, USA., Splawski I; Yarrow Biotechnology, New York, NY, USA., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Dominy JE; Biomedical Research at Novartis, Cambridge, MA, USA. john.e.dominy@outlook.com., Gurtan AM; Biomedical Research at Novartis, Cambridge, MA, USA. allan.gurtan@outlook.com., Saleheen D; Columbia University Irving Medical Center, New York, NY, USA. ds3792@cumc.columbia.edu.; Center for Non-Communicable Diseases, Karachi, Pakistan. ds3792@cumc.columbia.edu.
Corporate Authors: Regeneron Genetics Center
Source: Nature [Nature] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource.
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  Data: <searchLink fieldCode="AU" term="%22Koch+C%22">Koch C</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA. christopher-1.koch@novartis.com.<br /><searchLink fieldCode="AU" term="%22Khalid+S%22">Khalid S</searchLink>; Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+MZ%22">Khan MZ</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bandyadka+S%22">Bandyadka S</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doyon+B%22">Doyon B</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Denning+DP%22">Denning DP</searchLink>; Biomedical Research at Novartis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jahanzaib+M%22">Jahanzaib M</searchLink>; Center for Non-Communicable Diseases, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mian+MR%22">Mian MR</searchLink>; 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      – PersonEntity:
          Name:
            NameFull: Mahmood A
      – PersonEntity:
          Name:
            NameFull: Wazir MN
      – PersonEntity:
          Name:
            NameFull: Khan SJ
      – PersonEntity:
          Name:
            NameFull: Khan MA
      – PersonEntity:
          Name:
            NameFull: Ghaffar R
      – PersonEntity:
          Name:
            NameFull: Jan S
      – PersonEntity:
          Name:
            NameFull: Ul Hadi N
      – PersonEntity:
          Name:
            NameFull: Anjum R
      – PersonEntity:
          Name:
            NameFull: Abdullah R
      – PersonEntity:
          Name:
            NameFull: Musharraf MU
      – PersonEntity:
          Name:
            NameFull: Bashir MT
      – PersonEntity:
          Name:
            NameFull: Ali M
      – PersonEntity:
          Name:
            NameFull: Majeed I
      – PersonEntity:
          Name:
            NameFull: Bilal MH
      – PersonEntity:
          Name:
            NameFull: Khan SA
      – PersonEntity:
          Name:
            NameFull: Hata C
      – PersonEntity:
          Name:
            NameFull: Kou I
      – PersonEntity:
          Name:
            NameFull: Asaumi M
      – PersonEntity:
          Name:
            NameFull: Morii W
      – PersonEntity:
          Name:
            NameFull: Smith KR
      – PersonEntity:
          Name:
            NameFull: Kundu K
      – PersonEntity:
          Name:
            NameFull: Lythgow K
      – PersonEntity:
          Name:
            NameFull: MacArthur S
      – PersonEntity:
          Name:
            NameFull: Wasilewski S
      – PersonEntity:
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            NameFull: Petrovski S
      – PersonEntity:
          Name:
            NameFull: Rodriguez-Flores JL
      – PersonEntity:
          Name:
            NameFull: Riaz M
      – PersonEntity:
          Name:
            NameFull: Kapoor M
      – PersonEntity:
          Name:
            NameFull: Backman JD
      – PersonEntity:
          Name:
            NameFull: Shuldiner AR
      – PersonEntity:
          Name:
            NameFull: Bradner JE
      – PersonEntity:
          Name:
            NameFull: Splawski I
      – PersonEntity:
          Name:
            NameFull: Rasheed A
      – PersonEntity:
          Name:
            NameFull: Dominy JE
      – PersonEntity:
          Name:
            NameFull: Gurtan AM
      – PersonEntity:
          Name:
            NameFull: Saleheen D
    IsPartOfRelationships:
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          Dates:
            – D: 17
              M: 06
              Text: 2026 Jun 17
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1