Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.

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Title: Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.
Authors: Rhee M; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee J; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Jung CW; College of Pharmacy, Seoul National University, Seoul 08826, Korea., Yang J; Department of Biochemistry and Convergence Medical Science, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Choi WG; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., You YH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Park HS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee EY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee EK; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Kwon SW; College of Pharmacy, Seoul National University, Seoul 08826, Korea., Kim YB; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Lee SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. Electronic address: hwanx2@catholic.ac.kr.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.06.031