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Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain.

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Title: Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain.
Authors: Wu H; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Chen D; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China., Li J; College of Life Science, Liaoning Normal University, Dalian, China., Zhou T; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China., Zhuang Z; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Niu Z; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China., Du Z; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Chen Y; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Chuan S; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Xu C; BGI Research, Sanya, China., Liao X; BGI Research, Shenzhen, China., Meng X; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Lu J; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Cui W; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Lin Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China., Huang F; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China., Liao K; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China., Liu Y; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Yang T; BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGl Research, Shenzhen, China., Chen J; BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGl Research, Shenzhen, China., Wang H; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China., Dong Z; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China., Liu L; BGI Research, Hangzhou, China., Fang X; BGI Research, Hangzhou, China., Xu X; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Li Q; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Pang Y; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China., Liu S; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Su B; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.
Source: Science (New York, N.Y.) [Science] 2026 Jun 18; Vol. 392 (6804), pp. eaea2535. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain.
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  Data: <searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+Z%22">Zhuang Z</searchLink>; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Niu+Z%22">Niu Z</searchLink>; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Du+Z%22">Du Z</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chuan+S%22">Chuan S</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; BGI Research, Sanya, China.<br /><searchLink fieldCode="AU" term="%22Liao+X%22">Liao X</searchLink>; BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Meng+X%22">Meng X</searchLink>; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Cui+W%22">Cui W</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+F%22">Huang F</searchLink>; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liao+K%22">Liao K</searchLink>; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGl Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGl Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Dong+Z%22">Dong Z</searchLink>; College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fang+X%22">Fang X</searchLink>; BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Pang+Y%22">Pang Y</searchLink>; College of Life Science, Liaoning Normal University, Dalian, China.; Lamprey Research Center, Liaoning Normal University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; BGI Research, Hangzhou, China.; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Su+B%22">Su B</searchLink>; State Key Laboratory of Genetic Evolution and Animal Model, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jun 18; Vol. 392 (6804), pp. eaea2535. <i>Date of Electronic Publication: </i>2026 Jun 18.
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