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Timing matters: sex differences in treatment limitation decisions in intensive care.

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Title: Timing matters: sex differences in treatment limitation decisions in intensive care.
Authors: Amacher SA; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Department of Anesthesiology and Critical Care, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany., Gebert P; Institute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Tröster V; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland., Mikail N; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland., Vinzens A; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland., Regitz-Zagrosek V; Institute of Gender in Medicine (GiM), Charité - Universitätsmedizin Berlin, Berlin, Germany., Arslani K; Department of Cardiology, University Hospital Basel, Basel, Switzerland., Helms J; Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France., Merdji H; Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France., Long MT; Department of Anesthesiology and Critical Care, University of Wisconsin Hospitals and Clinics, Madison, USA., Hunziker S; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland., Lohri M; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Anesthesiology, University Hospital Basel, Basel, Switzerland., Grzonka P; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland., Berger S; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Interdepartmental Division of Critical Care, University Health Network, Toronto, Canada., Hollinger A; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland., Wildi K; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.; Intensive Care Unit, Cantonal Hospital Aarau, Aarau, Switzerland., Yuen B; Intensive Care Unit, Stadtspital Zürich Triemli, Zurich, Switzerland., Kaufmann M; University of Basel, Basel, Switzerland., Sutter R; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital Basel, Basel, Switzerland., Siegemund M; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland., Gebhard C; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.; Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland., Gebhard CE; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland. evacaroline.gebhard@unibas.ch.; University of Basel, Basel, Switzerland. evacaroline.gebhard@unibas.ch.; Intensive Care Unit, Stadtspital Zürich Triemli, Zurich, Switzerland. evacaroline.gebhard@unibas.ch.
Corporate Authors: Swiss ICU Trial Group
Source: Critical care (London, England) [Crit Care] 2026 Jun 19; Vol. 30 (1). Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Amacher+SA%22">Amacher SA</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Department of Anesthesiology and Critical Care, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gebert+P%22">Gebert P</searchLink>; Institute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tröster+V%22">Tröster V</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mikail+N%22">Mikail N</searchLink>; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vinzens+A%22">Vinzens A</searchLink>; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Regitz-Zagrosek+V%22">Regitz-Zagrosek V</searchLink>; Institute of Gender in Medicine (GiM), Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Arslani+K%22">Arslani K</searchLink>; Department of Cardiology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Helms+J%22">Helms J</searchLink>; Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Merdji+H%22">Merdji H</searchLink>; Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Long+MT%22">Long MT</searchLink>; Department of Anesthesiology and Critical Care, University of Wisconsin Hospitals and Clinics, Madison, USA.<br /><searchLink fieldCode="AU" term="%22Hunziker+S%22">Hunziker S</searchLink>; Medical Communication and Psychosomatic Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lohri+M%22">Lohri M</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Anesthesiology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grzonka+P%22">Grzonka P</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Berger+S%22">Berger S</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; Interdepartmental Division of Critical Care, University Health Network, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Hollinger+A%22">Hollinger A</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wildi+K%22">Wildi K</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.; Intensive Care Unit, Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yuen+B%22">Yuen B</searchLink>; Intensive Care Unit, Stadtspital Zürich Triemli, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kaufmann+M%22">Kaufmann M</searchLink>; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sutter+R%22">Sutter R</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Siegemund+M%22">Siegemund M</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.; University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gebhard+C%22">Gebhard C</searchLink>; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.; Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gebhard+CE%22">Gebhard CE</searchLink>; Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland. evacaroline.gebhard@unibas.ch.; University of Basel, Basel, Switzerland. evacaroline.gebhard@unibas.ch.; Intensive Care Unit, Stadtspital Zürich Triemli, Zurich, Switzerland. evacaroline.gebhard@unibas.ch.
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