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Complementary efficacy of CD127-directed immunotherapy with lusvertikimab and ABL-targeting tyrosine kinase inhibitors in preclinical ABL-class-fusion-positive B-ALL.

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Title: Complementary efficacy of CD127-directed immunotherapy with lusvertikimab and ABL-targeting tyrosine kinase inhibitors in preclinical ABL-class-fusion-positive B-ALL.
Authors: Pinkle D; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Cornils M; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Dietterle A; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Laqua A; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany., Kurschies M; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Heymann J; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Funke E; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Fanter P; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Gupta DD; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Reimer C; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Mahachi DT; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Gehlert CL; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany., Winterberg D; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Vossen-Gajcy M; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Müller X; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Balow G; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Iben K; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Barz M; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Bastian L; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Baldus C; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Kowol M; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany., Kikvadze S; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany., Wurm AA; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany.; German Cancer Consortium (DKTK) Partner Site Dresden Dresden Germany., Logvinova E; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany., Vokuhl C; Section of Pediatric Pathology, Department of Pathology University Hospital Bonn Bonn Germany., Schmid JP; Research Unit Apoptosis in Hematopoietic Stem Cells Helmholtz Center Munich Munich Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells Helmholtz Center Munich Munich Germany., Klausz K; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Peipp M; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Schrappe M; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Baccelli I; OSE Immunotherapeutics Nantes France., Poirier N; OSE Immunotherapeutics Nantes France., Brüggemann M; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Cario G; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany., Schewe DM; Clinical Research Unit CATCH ALL KFO Kiel Germany.; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany., Lenk L; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.
Source: HemaSphere [Hemasphere] 2026 Jun 17; Vol. 10 (6), pp. e70407. Date of Electronic Publication: 2026 Jun 17 (Print Publication: 2026).
Publication Type: Letter
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Editorial & Opinion
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  Data: Complementary efficacy of CD127-directed immunotherapy with lusvertikimab and ABL-targeting tyrosine kinase inhibitors in preclinical ABL-class-fusion-positive B-ALL.
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  Data: <searchLink fieldCode="AU" term="%22Pinkle+D%22">Pinkle D</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Cornils+M%22">Cornils M</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Dietterle+A%22">Dietterle A</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Laqua+A%22">Laqua A</searchLink>; 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University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Mahachi+DT%22">Mahachi DT</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Gehlert+CL%22">Gehlert CL</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Winterberg+D%22">Winterberg D</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Vossen-Gajcy+M%22">Vossen-Gajcy M</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Müller+X%22">Müller X</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Balow+G%22">Balow G</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Iben+K%22">Iben K</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Barz+M%22">Barz M</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Bastian+L%22">Bastian L</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Baldus+C%22">Baldus C</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Kowol+M%22">Kowol M</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Kikvadze+S%22">Kikvadze S</searchLink>; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany.<br /><searchLink fieldCode="AU" term="%22Wurm+AA%22">Wurm AA</searchLink>; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany.; German Cancer Consortium (DKTK) Partner Site Dresden Dresden Germany.<br /><searchLink fieldCode="AU" term="%22Logvinova+E%22">Logvinova E</searchLink>; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany.<br /><searchLink fieldCode="AU" term="%22Vokuhl+C%22">Vokuhl C</searchLink>; Section of Pediatric Pathology, Department of Pathology University Hospital Bonn Bonn Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+JP%22">Schmid JP</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells Helmholtz Center Munich Munich Germany.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells Helmholtz Center Munich Munich Germany.<br /><searchLink fieldCode="AU" term="%22Klausz+K%22">Klausz K</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Peipp+M%22">Peipp M</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Schrappe+M%22">Schrappe M</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Baccelli+I%22">Baccelli I</searchLink>; OSE Immunotherapeutics Nantes France.<br /><searchLink fieldCode="AU" term="%22Poirier+N%22">Poirier N</searchLink>; OSE Immunotherapeutics Nantes France.<br /><searchLink fieldCode="AU" term="%22Brüggemann+M%22">Brüggemann M</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Medical Department II Hematology and Oncology University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Cario+G%22">Cario G</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Schewe+DM%22">Schewe DM</searchLink>; Clinical Research Unit CATCH ALL KFO Kiel Germany.; Department of Pediatric Hematology and Oncology University Hospital Dresden Dresden Germany.; National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany.<br /><searchLink fieldCode="AU" term="%22Lenk+L%22">Lenk L</searchLink>; Department of Pediatrics I, ALL-BFM Study Group Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO Kiel Germany.
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