LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.

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Title: LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.
Authors: Ramage DE; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Wieske LHE; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Crowe C; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Christensen JB; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., von Wilmowski TA; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK., Bannister Z; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Grant DW; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Nakasone MA; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Haubrich K; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Dorward M; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Tchasovnikarova IA; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK., Weekes MP; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK., Matheson NJ; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK., Bayin NS; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Timms RT; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK. Electronic address: rtt20@cam.ac.uk.
Source: Molecular cell [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2828-2842.e12. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1097-4164
DOI:10.1016/j.molcel.2026.06.014