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Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis.

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Title: Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis.
Authors: Boizard-Moracchini A; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Department of Immunology and Immunogenetics, Bordeaux University Hospital, Bordeaux, France., Msalbi D; INSERM U1262, UMR 7276, CRIBL, University of Limoges, Limoges, France., Huot-Marchand S; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France., Haymour L; INSERM U1262, UMR 7276, CRIBL, University of Limoges, Limoges, France., Lebrault E; INSERM U1262, UMR 7276, CRIBL, University of Limoges, Limoges, France., Tchen J; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France., Jekel T; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France., Galli G; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France., Brilland B; Service de Néphrologie-Dialyse-Transplantation, University of Angers, CHU Angers, Angers, France.; Univ Angers, Nantes Université, Inserm, CNRS, SFR ICAT, CRCI2NA, Angers, France., Mérillon N; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France.; Univ Angers, Nantes Université, Inserm, CNRS, SFR ICAT, CRCI2NA, Angers, France., Josensi C; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France., Lozano C; University of Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France., Mazars J; INSERM U1262, UMR 7276, CRIBL, University of Limoges, Limoges, France., Douard M; University of Bordeaux, INSERM U1045, Centre de Recherche Cardio-Thoracique de Bordeaux, Pessac, France., Danger Y; EFS Rennes, Rue Pierre Jean Gineste, Rennes, Cedex, France., Vérité F; EFS Rennes, Rue Pierre Jean Gineste, Rennes, Cedex, France., Barnetche T; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France., Lazaro E; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France.; Internal Medicine Department, Haut-Leveque, Bordeaux University Hospital, Pessac, France., Duffau P; Internal Medicine Department, Saint André, Bordeaux University Hospital, Bordeaux, France., Pfirmann P; Nephrology Department, Bordeaux University Hospital, Bordeaux, France., Magerus-Chatinet A; INSERM U1163. IMAGINE - Institut des Maladies Génétiques, Paris, France., Jean M; University of Rennes, CNRS, ISCR - UMR 6226, Rennes, France., Augusto JF; Service de Néphrologie-Dialyse-Transplantation, University of Angers, CHU Angers, Angers, France.; Univ Angers, Nantes Université, Inserm, CNRS, SFR ICAT, CRCI2NA, Angers, France., Armengaud J; University of Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France., Richez C; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France.; Department of Rheumatology, Pellegrin, Bordeaux University Hospital, Bordeaux, France., Vacher P; University of Bordeaux, INSERM U1045, Centre de Recherche Cardio-Thoracique de Bordeaux, Pessac, France., Legembre P; INSERM U1262, UMR 7276, CRIBL, University of Limoges, Limoges, France. patrick.legembre@inserm.fr.; CIRI-Centre International de Recherche en Infectiologie, Team GIMAP, Inserm, U1111, CNRS, UMR5308, Université Saint-Etienne, Bordeaux, France. patrick.legembre@inserm.fr., Blanco P; University of Bordeaux, CNRS, ImmunoConcEpT, UMR, Bordeaux, France. patrick.blanco@chu-bordeaux.fr.; Department of Immunology and Immunogenetics, Bordeaux University Hospital, Bordeaux, France. patrick.blanco@chu-bordeaux.fr.; Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, Bordeaux, France. patrick.blanco@chu-bordeaux.fr.
Source: Nature communications [Nat Commun] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-74452-8