Plasma p-Tau217 and Aβ42/Aβ40 mediate the association between minimal depressive symptoms and cognitive impairment.

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Title: Plasma p-Tau217 and Aβ42/Aβ40 mediate the association between minimal depressive symptoms and cognitive impairment.
Authors: Chen Y; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Wang Z; Innovation Center for Neurological Disorders and Department of Neurology, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China., Chen H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Li H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Zhang Z; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Cui H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China., Li S; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: Journal of neurology [J Neurol] 2026 Jun 20; Vol. 273 (7). Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1459
DOI:10.1007/s00415-026-13954-3