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Plasma p-Tau217 and Aβ42/Aβ40 mediate the association between minimal depressive symptoms and cognitive impairment.

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Title: Plasma p-Tau217 and Aβ42/Aβ40 mediate the association between minimal depressive symptoms and cognitive impairment.
Authors: Chen Y; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Wang Z; Innovation Center for Neurological Disorders and Department of Neurology, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China., Chen H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Li H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Zhang Z; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China., Cui H; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China., Li S; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: Journal of neurology [J Neurol] 2026 Jun 20; Vol. 273 (7). Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma p-Tau217 and Aβ42/Aβ40 mediate the association between minimal depressive symptoms and cognitive impairment.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Innovation Center for Neurological Disorders and Department of Neurology, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.<br /><searchLink fieldCode="AU" term="%22Cui+H%22">Cui H</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Human Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.; The Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang, 050017, China. lisha@hebmu.edu.cn.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Disease+Neuroimaging+Initiative%22">Alzheimer’s Disease Neuroimaging Initiative</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220423161%22">Journal of neurology</searchLink> [J Neurol] 2026 Jun 20; Vol. 273 (7). <i>Date of Electronic Publication: </i>2026 Jun 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0423161 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1459 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405354%22">03405354 </searchLink><i>NLM ISO Abbreviation: </i>J Neurol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00415-026-13954-3
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        Text: English
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              Text: 2026 Jun 20
              Type: published
              Y: 2026
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