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Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.

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Title: Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.
Authors: Xiang YX; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China., Zou FS; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China., Shi MF; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China., Xu Q; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China.
Source: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2026 Jun 15; Vol. 21, pp. 615799. Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101273481 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2005 (Electronic) Linking ISSN: 11769106 NLM ISO Abbreviation: Int J Chron Obstruct Pulmon Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.
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  Data: <searchLink fieldCode="AU" term="%22Xiang+YX%22">Xiang YX</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zou+FS%22">Zou FS</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shi+MF%22">Shi MF</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, People's Republic of China.
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  Data: <searchLink fieldCode="JN" term="%22101273481%22">International journal of chronic obstructive pulmonary disease</searchLink> [Int J Chron Obstruct Pulmon Dis] 2026 Jun 15; Vol. 21, pp. 615799. <i>Date of Electronic Publication: </i>2026 Jun 15 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22DOVE+Medical+Press%22">DOVE Medical Press </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>101273481 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1178-2005 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211769106%22">11769106 </searchLink><i>NLM ISO Abbreviation: </i>Int J Chron Obstruct Pulmon Dis <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.2147/COPD.S615799
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      – Code: eng
        Text: English
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        StartPage: 615799
    Titles:
      – TitleFull: Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.
        Type: main
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          Name:
            NameFull: Xiang YX
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            NameFull: Zou FS
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            NameFull: Shi MF
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            – D: 15
              M: 06
              Text: 2026 Jun 15
              Type: published
              Y: 2026
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              Value: 1178-2005
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              Value: 21
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            – TitleFull: International journal of chronic obstructive pulmonary disease
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