Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

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Title: Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.
Authors: Nomura M; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Raviram R; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Schiffman JS; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Bussema L; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lu V; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wheeler N; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Lee JJY; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Fan Y; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zheng MH; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Ruiz F; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland., Danish H; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Kellett S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Nusrat L; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Chaligne R; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Huse JT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yung WKA; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tanaka S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Saito N; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Das S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Potenski C; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Landau DA; New York Genome Center, New York, NY, USA. dal3005@med.cornell.edu.; Weill Cornell Medicine, New York, NY, USA. dal3005@med.cornell.edu., Suvà ML; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Suva.Mario@mgh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu.
Source: Nature genetics [Nat Genet] 2026 Jul; Vol. 58 (7), pp. 1651-1660. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-026-02642-7