Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.
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| Title: | Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. |
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| Authors: | Nomura M; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Raviram R; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Schiffman JS; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Bussema L; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lu V; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wheeler N; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Lee JJY; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Fan Y; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zheng MH; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Ruiz F; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland., Danish H; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Kellett S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Nusrat L; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Chaligne R; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Huse JT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yung WKA; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tanaka S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Saito N; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Das S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Potenski C; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Landau DA; New York Genome Center, New York, NY, USA. dal3005@med.cornell.edu.; Weill Cornell Medicine, New York, NY, USA. dal3005@med.cornell.edu., Suvà ML; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Suva.Mario@mgh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu. |
| Source: | Nature genetics [Nat Genet] 2026 Jul; Vol. 58 (7), pp. 1651-1660. Date of Electronic Publication: 2026 Jun 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42332268 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nomura+M%22">Nomura M</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Raviram+R%22">Raviram R</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schiffman+JS%22">Schiffman JS</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bussema+L%22">Bussema L</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+V%22">Lu V</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+N%22">Wheeler N</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJY%22">Lee JJY</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+MH%22">Zheng MH</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+F%22">Ruiz F</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Danish+H%22">Danish H</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kellett+S%22">Kellett S</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nusrat+L%22">Nusrat L</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chaligne+R%22">Chaligne R</searchLink>; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huse+JT%22">Huse JT</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yung+WKA%22">Yung WKA</searchLink>; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+S%22">Tanaka S</searchLink>; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+N%22">Saito N</searchLink>; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Potenski+C%22">Potenski C</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Landau+DA%22">Landau DA</searchLink>; New York Genome Center, New York, NY, USA. dal3005@med.cornell.edu.; Weill Cornell Medicine, New York, NY, USA. dal3005@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Suvà+ML%22">Suvà ML</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41588-026-02642-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1651 Titles: – TitleFull: Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nomura M – PersonEntity: Name: NameFull: Raviram R – PersonEntity: Name: NameFull: Schiffman JS – PersonEntity: Name: NameFull: Bussema L – PersonEntity: Name: NameFull: Lu V – PersonEntity: Name: NameFull: Wheeler N – PersonEntity: Name: NameFull: Lee JJY – PersonEntity: Name: NameFull: Fan Y – PersonEntity: Name: NameFull: Zheng MH – PersonEntity: Name: NameFull: Ruiz F – PersonEntity: Name: NameFull: Danish H – PersonEntity: Name: NameFull: Kellett S – PersonEntity: Name: NameFull: Nusrat L – PersonEntity: Name: NameFull: Chaligne R – PersonEntity: Name: NameFull: Huse JT – PersonEntity: Name: NameFull: Yung WKA – PersonEntity: Name: NameFull: Tanaka S – PersonEntity: Name: NameFull: Saito N – PersonEntity: Name: NameFull: Das S – PersonEntity: Name: NameFull: Potenski C – PersonEntity: Name: NameFull: Landau DA – PersonEntity: Name: NameFull: Suvà ML IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1546-1718 Numbering: – Type: volume Value: 58 – Type: issue Value: 7 Titles: – TitleFull: Nature genetics Type: main |
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