Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

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Title: Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.
Authors: Nomura M; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Raviram R; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Schiffman JS; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Bussema L; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lu V; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wheeler N; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Lee JJY; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Fan Y; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zheng MH; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Ruiz F; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland., Danish H; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Kellett S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Nusrat L; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Chaligne R; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Huse JT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yung WKA; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tanaka S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Saito N; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Das S; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Potenski C; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Landau DA; New York Genome Center, New York, NY, USA. dal3005@med.cornell.edu.; Weill Cornell Medicine, New York, NY, USA. dal3005@med.cornell.edu., Suvà ML; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Suva.Mario@mgh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu.
Source: Nature genetics [Nat Genet] 2026 Jul; Vol. 58 (7), pp. 1651-1660. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.
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  Data: <searchLink fieldCode="AU" term="%22Nomura+M%22">Nomura M</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Raviram+R%22">Raviram R</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schiffman+JS%22">Schiffman JS</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bussema+L%22">Bussema L</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+V%22">Lu V</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+N%22">Wheeler N</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJY%22">Lee JJY</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+MH%22">Zheng MH</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+F%22">Ruiz F</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Danish+H%22">Danish H</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kellett+S%22">Kellett S</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nusrat+L%22">Nusrat L</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chaligne+R%22">Chaligne R</searchLink>; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huse+JT%22">Huse JT</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yung+WKA%22">Yung WKA</searchLink>; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+S%22">Tanaka S</searchLink>; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+N%22">Saito N</searchLink>; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Potenski+C%22">Potenski C</searchLink>; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Landau+DA%22">Landau DA</searchLink>; New York Genome Center, New York, NY, USA. dal3005@med.cornell.edu.; Weill Cornell Medicine, New York, NY, USA. dal3005@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Suvà+ML%22">Suvà ML</searchLink>; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Suva.Mario@mgh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Suva.Mario@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Jul; Vol. 58 (7), pp. 1651-1660. <i>Date of Electronic Publication: </i>2026 Jun 22.
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