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Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6.

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Title: Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6.
Authors: Chen J; Department of breast surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China., Ren LX; Department of Hepatobiliary, Pancreatic and Gastrointestinal Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China., Ma Y; Department of Thoracic surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China., Cheng WH; Department of Gastroenterology, Shanxi Cancer Hospital, Taiyuan, Shanxi, China., Liu T; Department of Hepatobiliary, Pancreatic and Gastrointestinal Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China. liutingchenjing@163.com.; Department of General Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, China. liutingchenjing@163.com.
Source: Cancer cell international [Cancer Cell Int] 2026 Jun 22. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6.
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  Data: <searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of breast surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.<br /><searchLink fieldCode="AU" term="%22Ren+LX%22">Ren LX</searchLink>; Department of Hepatobiliary, Pancreatic and Gastrointestinal Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Thoracic surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.<br /><searchLink fieldCode="AU" term="%22Cheng+WH%22">Cheng WH</searchLink>; Department of Gastroenterology, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Department of Hepatobiliary, Pancreatic and Gastrointestinal Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China. liutingchenjing@163.com.; Department of General Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030032, China. liutingchenjing@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101139795%22">Cancer cell international</searchLink> [Cancer Cell Int] 2026 Jun 22. <i>Date of Electronic Publication: </i>2026 Jun 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101139795 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1475-2867 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752867%22">14752867 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell Int
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42332702
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      – Type: doi
        Value: 10.1186/s12935-026-04368-2
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        Text: English
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      – TitleFull: Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6.
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            NameFull: Ren LX
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            – D: 22
              M: 06
              Text: 2026 Jun 22
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              Y: 2026
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