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Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.

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Title: Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.
Authors: Fernández-Barrecheguren A; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain., Fernández-Rego A; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain., Fuentes-Cantos L; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain., Pons T; Department of Immunology and Oncology, CNB-CSIC, Madrid, Spain., Estrada BS; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain., Iborra-Pernichi M; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain., de la Esperanza MV; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain., Ebrahimi T; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain., Sagrega-Aparisi A; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain., Cogliati S; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain., Martínez-Martín N; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain., Jiménez-Saiz R; Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Madrid, Spain., Carrasco YR; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.
Source: Science signaling [Sci Signal] 2026 Jun 23; Vol. 19 (943), pp. eadw1017. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.
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  Data: <searchLink fieldCode="AU" term="%22Fernández-Barrecheguren+A%22">Fernández-Barrecheguren A</searchLink>; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Rego+A%22">Fernández-Rego A</searchLink>; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fuentes-Cantos+L%22">Fuentes-Cantos L</searchLink>; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.; Molecular Biosciences Program, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pons+T%22">Pons T</searchLink>; Department of Immunology and Oncology, CNB-CSIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Estrada+BS%22">Estrada BS</searchLink>; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Iborra-Pernichi+M%22">Iborra-Pernichi M</searchLink>; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+la+Esperanza+MV%22">de la Esperanza MV</searchLink>; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ebrahimi+T%22">Ebrahimi T</searchLink>; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sagrega-Aparisi+A%22">Sagrega-Aparisi A</searchLink>; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cogliati+S%22">Cogliati S</searchLink>; CBMSO, CSIC-UAM, Institute for Molecular Biology-IUBM, UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Martín+N%22">Martínez-Martín N</searchLink>; Organ and Tissue Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez-Saiz+R%22">Jiménez-Saiz R</searchLink>; Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Carrasco+YR%22">Carrasco YR</searchLink>; B Lymphocyte Dynamics, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2026 Jun 23; Vol. 19 (943), pp. eadw1017. <i>Date of Electronic Publication: </i>2026 Jun 23.
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