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Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation.

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Title: Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation.
Authors: Oliveira F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.; Faculty of Medicine, University of Leipzig, Leipzig, Germany., Papa C; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Hagemann T; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Schipper R; Department of Medicine Solna, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Geier F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Röxe T; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany., Zulfqar F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Prönnecke C; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Schmidt L; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Stryhanyuk H; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Kyselova A; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Karantanou C; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Buckley Y; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Farhan MA; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany., Rodríguez-Aguilera JR; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Ambreen S; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany., Yao H; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Arif A; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany., Martin HNG; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Ebert T; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Klöting N; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Shahzad K; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany., Boeckel JN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany., Hagberg CE; Department of Medicine Solna, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Chakaroun R; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Bibli SI; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Heidelberg University, Heidelberg, Germany., Sheikh BN; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany. bilal.sheikh@helmholtz-munich.de.; Faculty of Medicine, University of Leipzig, Leipzig, Germany. bilal.sheikh@helmholtz-munich.de.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany. bilal.sheikh@helmholtz-munich.de.; German Centre for Diabetes Research (DZD), Neuherberg, Germany. bilal.sheikh@helmholtz-munich.de.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jun 23; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation.
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  Data: <searchLink fieldCode="AU" term="%22Oliveira+F%22">Oliveira F</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.; Faculty of Medicine, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Papa+C%22">Papa C</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hagemann+T%22">Hagemann T</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schipper+R%22">Schipper R</searchLink>; Department of Medicine Solna, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Geier+F%22">Geier F</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Röxe+T%22">Röxe T</searchLink>; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Zulfqar+F%22">Zulfqar F</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Prönnecke+C%22">Prönnecke C</searchLink>; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+L%22">Schmidt L</searchLink>; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Stryhanyuk+H%22">Stryhanyuk H</searchLink>; Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+A%22">Hoffmann A</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kyselova+A%22">Kyselova A</searchLink>; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Karantanou+C%22">Karantanou C</searchLink>; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Buckley+Y%22">Buckley Y</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Farhan+MA%22">Farhan MA</searchLink>; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Aguilera+JR%22">Rodríguez-Aguilera JR</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Ambreen+S%22">Ambreen S</searchLink>; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Arif+A%22">Arif A</searchLink>; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Martin+HNG%22">Martin HNG</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Ebert+T%22">Ebert T</searchLink>; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Klöting+N%22">Klöting N</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Blüher+M%22">Blüher M</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Shahzad+K%22">Shahzad K</searchLink>; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Boeckel+JN%22">Boeckel JN</searchLink>; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hagberg+CE%22">Hagberg CE</searchLink>; Department of Medicine Solna, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Chakaroun+R%22">Chakaroun R</searchLink>; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Bibli+SI%22">Bibli SI</searchLink>; European Center for Angioscience, Department of Vascular Dysfunction, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sheikh+BN%22">Sheikh BN</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, Leipzig, Germany. bilal.sheikh@helmholtz-munich.de.; Faculty of Medicine, University of Leipzig, Leipzig, Germany. bilal.sheikh@helmholtz-munich.de.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany. bilal.sheikh@helmholtz-munich.de.; German Centre for Diabetes Research (DZD), Neuherberg, Germany. bilal.sheikh@helmholtz-munich.de.
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