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Application of a Novel Desirability of Outcome Ranking Endpoint Incorporating a Framework for Resistance Assessment and Microbiologic Evaluation in Antibiotic Trials: A Proof-of-Concept in a Post Hoc Analysis of the BALANCE Trial.

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Title: Application of a Novel Desirability of Outcome Ranking Endpoint Incorporating a Framework for Resistance Assessment and Microbiologic Evaluation in Antibiotic Trials: A Proof-of-Concept in a Post Hoc Analysis of the BALANCE Trial.
Authors: Ong SWX; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; ICES, Toronto, Ontario, Canada., Patrikar A; ICES, Toronto, Ontario, Canada., Pinto R; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Mahar RK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Methods and Implementation Support for Clinical and Health Research Hub, University of Melbourne, Parkville, Victoria, Australia., Rishu A; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Davis JS; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.; Department of Immunology and Infectious Diseases, John Hunter Hospital, Newcastle, New South Wales, Australia.; Global and Tropical Health Division, Menzies School of Health and Research, Darwin, Northern Territory, Australia., Fowler RA; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Tong SYC; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Daneman N; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.
Source: Open forum infectious diseases [Open Forum Infect Dis] 2026 Jun 22; Vol. 13 (6), pp. ofag142. Date of Electronic Publication: 2026 Jun 22 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Application of a Novel Desirability of Outcome Ranking Endpoint Incorporating a Framework for Resistance Assessment and Microbiologic Evaluation in Antibiotic Trials: A Proof-of-Concept in a Post Hoc Analysis of the BALANCE Trial.
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  Data: <searchLink fieldCode="AU" term="%22Ong+SWX%22">Ong SWX</searchLink>; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Patrikar+A%22">Patrikar A</searchLink>; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pinto+R%22">Pinto R</searchLink>; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mahar+RK%22">Mahar RK</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Methods and Implementation Support for Clinical and Health Research Hub, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rishu+A%22">Rishu A</searchLink>; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+JS%22">Davis JS</searchLink>; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.; Department of Immunology and Infectious Diseases, John Hunter Hospital, Newcastle, New South Wales, Australia.; Global and Tropical Health Division, Menzies School of Health and Research, Darwin, Northern Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Fowler+RA%22">Fowler RA</searchLink>; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tong+SYC%22">Tong SYC</searchLink>; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Daneman+N%22">Daneman N</searchLink>; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101637045%22">Open forum infectious diseases</searchLink> [Open Forum Infect Dis] 2026 Jun 22; Vol. 13 (6), pp. ofag142. <i>Date of Electronic Publication: </i>2026 Jun 22 (<i>Print Publication: </i>2026).
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