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Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study.

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Title: Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study.
Authors: Pontes CDN; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil., Zampieri FG; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Department of Critical Care Medicine, University of Alberta - Alberta, Canada., Figueiredo RC; Hospital São José, Centro Universitário do Espírito Santo - Colatina (ES), Brazil., Pedro RAM; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil., Malbouisson LMS; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Anesthesiology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil., Cunha RCD; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil., Ramos FJDS; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil., Damiani LP; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil., Besen BAMP; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil., Freitas FGR; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil., Machado FR; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.
Source: Critical care science [Crit Care Sci] 2026 Jun 22; Vol. 38, pp. e20260300. Date of Electronic Publication: 2026 Jun 22 (Print Publication: 2026).
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Associação de Medicina Intensiva Brasileira Country of Publication: Brazil NLM ID: 9918627781706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2965-2774 (Electronic) Linking ISSN: 29652774 NLM ISO Abbreviation: Crit Care Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2965-2774
DOI:10.62675/2965-2774.20260300