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Sex differences in Drosophila intestinal metabolism contribute to sexually dimorphic infection outcome and alter gut pathogen virulence.

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Title: Sex differences in Drosophila intestinal metabolism contribute to sexually dimorphic infection outcome and alter gut pathogen virulence.
Authors: Rubinić M; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany.; Faculty of Life Sciences, Humboldt-Universität zu Berlin, Berlin 10099, Germany., Yu Y; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Arias-Rojas A; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Martinez KA; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Klimek W; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Frahm D; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Brinkmann V; Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin 10117, Germany., Paczia N; Core Facility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany., Alagesan K; Max Planck Unit for the Science of Pathogens, Berlin 10117, Germany., Duneau D; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.; Center for Ecology, Evolution and Environmental Changes and Global Change and Sustainability Institute, Faculty of Sciences, University of Lisbon, Lisbon 1749-016, Portugal., Iatsenko I; Research group Genetics of host-microbe interactions, Max Planck Institute for Infection Biology, Berlin 10117, Germany.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 30; Vol. 123 (26), pp. e2514992123. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2514992123