The importance of integrating genetic testing into reproductive medicine: a retrospective observational study investigating the monogenic causes of human infertility in couples considering ICSI.

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Title: The importance of integrating genetic testing into reproductive medicine: a retrospective observational study investigating the monogenic causes of human infertility in couples considering ICSI.
Authors: El-Dessouky SH; Prenatal Diagnosis & Fetal Medicine Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Sharaf-Eldin WE; Medical Molecular Genetics Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Soliman IF; Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt.; Armed Forces College of Medicine - Andrology Unit, Cairo, Egypt., M Aboulghar M; Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt., Abou El-Serour A; Department of Obstetrics and Gynecology, Al Azhar University, Cairo, Egypt., Ali A; Department of Reproductive Health and Family Planning, National Research Centre, Cairo, Egypt., Senousy S; Prenatal Diagnosis & Fetal Medicine Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Matsa L; Genomic Precision Diagnostic Department, Igenomix, Dubai, United Arab Emirates., Maher M; Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.; South Tees Hospitals, Middlesbrough, United Kingdom., Zolfokar DS; Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt., Youssef MA; Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt., Mousa HA; Maternal and Fetal Medicine Unit, University Hospitals of Leicester NHS Trust, Leicester, UK., Eid MM; Human Cytogenetics Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Zaki MS; Clinical Genetics Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt., Abdalla EM; Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. ebtesam.nasr@alexu.edu.eg.
Source: Journal of human genetics [J Hum Genet] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-232X (Electronic) Linking ISSN: 14345161 NLM ISO Abbreviation: J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1435-232X
DOI:10.1038/s10038-026-01485-8