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A 3D pooled PBMC-organoid co-culture platform for profiling immune susceptibility and PD-1 blockade response in gastric cancer.

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Title: A 3D pooled PBMC-organoid co-culture platform for profiling immune susceptibility and PD-1 blockade response in gastric cancer.
Authors: Mun HB; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Kwon WS; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Park CH; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Koo H; Department of Medical Science Convergence, Graduate School of Medical Science, University of Ulsan, Ulsan, Republic of Korea., Jang J; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Yoon BG; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Park J; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Moon YJ; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Lee CK; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea., Jeung HC; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Medical Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim TS; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea., Rha SY; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. RHA7655@yuhs.ac.; Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea. RHA7655@yuhs.ac.; Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. RHA7655@yuhs.ac.; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. RHA7655@yuhs.ac.
Source: BMC medicine [BMC Med] 2026 Jun 24. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1741-7015
DOI:10.1186/s12916-026-05006-4