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Studying Early Life Live-Attenuated influenza virus immune Responses (STELLAR): study protocol for an exploratory observational study of the nasal mucosal and systemic immune response in healthy children given an intranasal live-attenuated influenza vaccine.

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Title: Studying Early Life Live-Attenuated influenza virus immune Responses (STELLAR): study protocol for an exploratory observational study of the nasal mucosal and systemic immune response in healthy children given an intranasal live-attenuated influenza vaccine.
Authors: Kelleher K; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Bennett R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Jackson R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ivaska L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Singh N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Quintero Barceinas RS; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Francis E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Nwankwo C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Francis-Hill J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Thompson A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Solórzano C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Baughan H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Didierlaurent AM; Center of Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, GE, Switzerland., Urban BC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ferreira DM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK daniela.ferreira@paediatrics.ox.ac.uk., Kelly D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Source: BMJ open [BMJ Open] 2026 Jun 25; Vol. 16 (6), pp. e114107. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Studying Early Life Live-Attenuated influenza virus immune Responses (STELLAR): study protocol for an exploratory observational study of the nasal mucosal and systemic immune response in healthy children given an intranasal live-attenuated influenza vaccine.
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  Data: <searchLink fieldCode="AU" term="%22Kelleher+K%22">Kelleher K</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bennett+R%22">Bennett R</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+R%22">Jackson R</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ivaska+L%22">Ivaska L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Quintero+Barceinas+RS%22">Quintero Barceinas RS</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Plested+E%22">Plested E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Francis+E%22">Francis E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mujadidi+YF%22">Mujadidi YF</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Nwankwo+C%22">Nwankwo C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Francis-Hill+J%22">Francis-Hill J</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+A%22">Thompson A</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Solórzano+C%22">Solórzano C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Baughan+H%22">Baughan H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Didierlaurent+AM%22">Didierlaurent AM</searchLink>; Center of Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, GE, Switzerland.<br /><searchLink fieldCode="AU" term="%22Urban+BC%22">Urban BC</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ferreira+DM%22">Ferreira DM</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK daniela.ferreira@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Kelly+D%22">Kelly D</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
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