Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis.

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Title: Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis.
Authors: Bishop MS; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Pustovit RV; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Jufar AH; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Lane DJR; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., May CN; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia., Ayton S; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia., Plummer MP; Department of Intensive Care, Royal Adelaide Hospital, Adelaide, Australia.; School of Medicine, University of Adelaide, Adelaide, Australia., Ow CPC; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Lankadeva YR; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Anesthesia, Austin Hospital, Heidelberg, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Translational Cardiovascular and Renal Research Group, Stroke and Critical Care Priority Research Area, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. yugeesh.lankadeva@florey.edu.au.
Source: Scientific reports [Sci Rep] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-59679-1