Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis.
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| Title: | Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis. |
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| Authors: | Bishop MS; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Pustovit RV; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Jufar AH; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Lane DJR; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., May CN; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia., Ayton S; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia., Plummer MP; Department of Intensive Care, Royal Adelaide Hospital, Adelaide, Australia.; School of Medicine, University of Adelaide, Adelaide, Australia., Ow CPC; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia., Lankadeva YR; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Anesthesia, Austin Hospital, Heidelberg, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Translational Cardiovascular and Renal Research Group, Stroke and Critical Care Priority Research Area, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. yugeesh.lankadeva@florey.edu.au. |
| Source: | Scientific reports [Sci Rep] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42350542 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bishop+MS%22">Bishop MS</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pustovit+RV%22">Pustovit RV</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jufar+AH%22">Jufar AH</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lane+DJR%22">Lane DJR</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22May+CN%22">May CN</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ayton+S%22">Ayton S</searchLink>; Translational Neurodegeneration Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Plummer+MP%22">Plummer MP</searchLink>; Department of Intensive Care, Royal Adelaide Hospital, Adelaide, Australia.; School of Medicine, University of Adelaide, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Ow+CPC%22">Ow CPC</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lankadeva+YR%22">Lankadeva YR</searchLink>; Translational Cardiovascular and Renal Research Group, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Anesthesia, Austin Hospital, Heidelberg, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Translational Cardiovascular and Renal Research Group, Stroke and Critical Care Priority Research Area, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. yugeesh.lankadeva@florey.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 25. <i>Date of Electronic Publication: </i>2026 Jun 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42350542 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-026-59679-1 Languages: – Code: eng Text: English Titles: – TitleFull: Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bishop MS – PersonEntity: Name: NameFull: Pustovit RV – PersonEntity: Name: NameFull: Jufar AH – PersonEntity: Name: NameFull: Lane DJR – PersonEntity: Name: NameFull: May CN – PersonEntity: Name: NameFull: Ayton S – PersonEntity: Name: NameFull: Plummer MP – PersonEntity: Name: NameFull: Ow CPC – PersonEntity: Name: NameFull: Lankadeva YR IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 06 Text: 2026 Jun 25 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2045-2322 Titles: – TitleFull: Scientific reports Type: main |
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