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Outcomes of patients with chronic lymphocytic leukemia discontinuing covalent Bruton tyrosine kinase inhibitors due to adverse events.

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Title: Outcomes of patients with chronic lymphocytic leukemia discontinuing covalent Bruton tyrosine kinase inhibitors due to adverse events.
Authors: Mansour AG; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Huang Y; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Pemberton JP; Department of Internal Medicine, Virginia Commonwealth University, Health System, Richmond, VA, USA., Alsouqi A; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Kittai AS; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Byrd JC; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Grever MR; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Miller C; Department of Pathology, The Ohio State University, Columbus, OH, USA., Lozanski G; Department of Pathology, The Ohio State University, Columbus, OH, USA., Wiczer T; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA., Lundberg J; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA., Rosen L; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA., Crawford C; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA., Everhart T; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA., Moran M; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Lucas M; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Hinton S; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Grantier C; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Hoffman C; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Reid M; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Rogers KA; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Bhat SA; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Woyach JA; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. jennifer.woyach@osumc.edu.
Source: Leukemia [Leukemia] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mansour+AG%22">Mansour AG</searchLink>; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pemberton+JP%22">Pemberton JP</searchLink>; Department of Internal Medicine, Virginia Commonwealth University, Health System, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Alsouqi+A%22">Alsouqi A</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kittai+AS%22">Kittai AS</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Byrd+JC%22">Byrd JC</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Grever+MR%22">Grever MR</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Miller+C%22">Miller C</searchLink>; Department of Pathology, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lozanski+G%22">Lozanski G</searchLink>; Department of Pathology, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wiczer+T%22">Wiczer T</searchLink>; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lundberg+J%22">Lundberg J</searchLink>; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+L%22">Rosen L</searchLink>; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+C%22">Crawford C</searchLink>; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Everhart+T%22">Everhart T</searchLink>; Department of Pharmacy, The Ohio State University Arthur G James Cancer Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Moran+M%22">Moran M</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lucas+M%22">Lucas M</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hinton+S%22">Hinton S</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Grantier+C%22">Grantier C</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+C%22">Hoffman C</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Reid+M%22">Reid M</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+KA%22">Rogers KA</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bhat+SA%22">Bhat SA</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Woyach+JA%22">Woyach JA</searchLink>; Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. jennifer.woyach@osumc.edu.
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