Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge.

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Title: Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge.
Authors: Rudometova NB; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Ivanova KI; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Fomenko VV; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Rudometov AP; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Kisakova LA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Kisakov DN; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Yakovleva EV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Yakovlev VA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Makarova KP; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Vakhitov DI; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Borgoyakova MB; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Starostina EV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Zaitsev BN; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Litvinova VR; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Pyankov SA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Ilyicheva TN; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Ilyichev AA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Gudymo AS; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Marchenko VY; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Agafonov AP; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia., Karpenko LI; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.
Source: Pharmaceutics [Pharmaceutics] 2026 May 28; Vol. 18 (6). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge.
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  Data: <searchLink fieldCode="AU" term="%22Rudometova+NB%22">Rudometova NB</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Ivanova+KI%22">Ivanova KI</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Fomenko+VV%22">Fomenko VV</searchLink>; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Rudometov+AP%22">Rudometov AP</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Kisakova+LA%22">Kisakova LA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Kisakov+DN%22">Kisakov DN</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Yakovleva+EV%22">Yakovleva EV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Yakovlev+VA%22">Yakovlev VA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Makarova+KP%22">Makarova KP</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Vakhitov+DI%22">Vakhitov DI</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Borgoyakova+MB%22">Borgoyakova MB</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Starostina+EV%22">Starostina EV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Zaitsev+BN%22">Zaitsev BN</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Litvinova+VR%22">Litvinova VR</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Pyankov+SA%22">Pyankov SA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Ilyicheva+TN%22">Ilyicheva TN</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Ilyichev+AA%22">Ilyichev AA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Gudymo+AS%22">Gudymo AS</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Marchenko+VY%22">Marchenko VY</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Salakhutdinov+NF%22">Salakhutdinov NF</searchLink>; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Agafonov+AP%22">Agafonov AP</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Karpenko+LI%22">Karpenko LI</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, 630559 Koltsovo, Russia.
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              Text: 2026 May 28
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