SIRT3/AARS2 regulates SOD2 lactylation to determine neuronal fate in TBI.

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Title: SIRT3/AARS2 regulates SOD2 lactylation to determine neuronal fate in TBI.
Authors: Song J; Department of Emergency Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China.; Department of Critical Care Medicine, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, 611130, China., Liu J; Department of Anesthesiology, Chengdu Fifth People's Hospital, (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, 611130, China., Fan W; Department of Hyperbaric Oxygen Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China., Gou F; Department of Emergency Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China., Yang H; Department of Emergency Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China., Wang P; Department of Critical Care Medicine, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, 611130, China. 2710924996@qq.com., Yang X; Department of Emergency Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China. bacelona1978@163.com., Tao K; Department of Emergency Medicine, The General Hospital of Western Theater Command (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China. taokai08@163.com.; Department of Experimental Surgery, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710000, Shaanxi Province, China. taokai08@163.com.
Source: Molecular neurobiology [Mol Neurobiol] 2026 Jun 26; Vol. 63 (1). Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-1182
DOI:10.1007/s12035-026-05931-8