Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure.

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Title: Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure.
Authors: Wu Z; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Zheng Z; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Li Y; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Li B; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Pi S; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Wu D; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Chen Z; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Li X; Guizhou Precision Medicine Institute, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Li W; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China., Dai F; Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.; Guizhou Medical University, Guiyang, Guizhou, China.
Source: PloS one [PLoS One] 2026 Jun 26; Vol. 21 (6), pp. e0352124. Date of Electronic Publication: 2026 Jun 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0352124