Treg cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I-deficient metastatic pancreatic cancer.
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| Authors: | Schmiechen ZC; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Cruz-Hinojoza E; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Hilk AL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Ellefson MA; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Tsai AK; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Dres OM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kang LI; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Geuenich MJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Butler JZ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Burrack AL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Larsen BM; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Hickok GH; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Miller EA; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Lonetree CL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Gaire A; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Pandey R; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Nanda HA; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Chaudhury I; Caris Life Sciences, Phoenix, AZ, USA., Corbiere T; Caris Life Sciences, Phoenix, AZ, USA., Dileepan T; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Shen SS; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Campbell KR; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Division of Oncology, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada., DeNardo DG; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Stromnes IM; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA. |
| Source: | Science immunology [Sci Immunol] 2026 Jun 26; Vol. 11 (120), pp. eadz4302. Date of Electronic Publication: 2026 Jun 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adz4302 |
