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Treg cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I-deficient metastatic pancreatic cancer.

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Title: Treg cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I-deficient metastatic pancreatic cancer.
Authors: Schmiechen ZC; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Cruz-Hinojoza E; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Hilk AL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Ellefson MA; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Tsai AK; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Dres OM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kang LI; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Geuenich MJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Butler JZ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Burrack AL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Larsen BM; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Hickok GH; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Miller EA; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Lonetree CL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Gaire A; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Pandey R; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Nanda HA; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Chaudhury I; Caris Life Sciences, Phoenix, AZ, USA., Corbiere T; Caris Life Sciences, Phoenix, AZ, USA., Dileepan T; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Shen SS; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA., Campbell KR; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Division of Oncology, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada., DeNardo DG; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Stromnes IM; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.
Source: Science immunology [Sci Immunol] 2026 Jun 26; Vol. 11 (120), pp. eadz4302. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: T<subscript>reg</subscript> cells promote immunotherapy-induced immune evasion by restraining CD4 T cell control of MHC-I-deficient metastatic pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Schmiechen+ZC%22">Schmiechen ZC</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cruz-Hinojoza+E%22">Cruz-Hinojoza E</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hilk+AL%22">Hilk AL</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ellefson+MA%22">Ellefson MA</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+AK%22">Tsai AK</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dres+OM%22">Dres OM</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kang+LI%22">Kang LI</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Geuenich+MJ%22">Geuenich MJ</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Butler+JZ%22">Butler JZ</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Burrack+AL%22">Burrack AL</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Larsen+BM%22">Larsen BM</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hickok+GH%22">Hickok GH</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Miller+EA%22">Miller EA</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lonetree+CL%22">Lonetree CL</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gaire+A%22">Gaire A</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+R%22">Pandey R</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Nanda+HA%22">Nanda HA</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhury+I%22">Chaudhury I</searchLink>; Caris Life Sciences, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Corbiere+T%22">Corbiere T</searchLink>; Caris Life Sciences, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Dileepan+T%22">Dileepan T</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Shen+SS%22">Shen SS</searchLink>; Institute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN, USA.; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+KR%22">Campbell KR</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Division of Oncology, Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22DeNardo+DG%22">DeNardo DG</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Stromnes+IM%22">Stromnes IM</searchLink>; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.
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