Affinity- and epitope-dependent pathogenicity of GM-CSF autoantibodies in patients with autoimmune pulmonary alveolar proteinosis.
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| Title: | Affinity- and epitope-dependent pathogenicity of GM-CSF autoantibodies in patients with autoimmune pulmonary alveolar proteinosis. |
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| Authors: | Futami S; Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.; Department of Respiratory Medicine, NHO Osaka National Hospital, Osaka, Japan., Kawai C; Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan., Kishikawa JI; Laboratory of Cryo-EM Structural Biology, Institute for Protein Research, The University of Osaka, Osaka, Japan.; Faculty of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan., Hirose M; Clinical Research Center, NHO Kinki Chuo Chest Medical Center, Osaka, Japan., Kida H; Department of Respiratory Medicine, NHO Osaka Toneyama Medical Center, Osaka, Japan., Wang PH; KOTAI Biotechnologies, Inc., Osaka, Japan., Yamashita K; KOTAI Biotechnologies, Inc., Osaka, Japan., Ishikawa F; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Kato T; Laboratory of Cryo-EM Structural Biology, Institute for Protein Research, The University of Osaka, Osaka, Japan., Inoue Y; Clinical Research Center, NHO Kinki Chuo Chest Medical Center, Osaka, Japan.; Department of Internal Medicine, Osaka Anti-tuberculosis Association, Osaka Fukujuji Hospital, Osaka, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.; Department of Immunopathology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, Osaka, Japan.; Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Osaka, Japan.; Japan Agency for Medical Research and Development - Core Research for Evolutional Science and Technology (AMED-CREST), The University of Osaka, Osaka, Japan.; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, Osaka, Japan., Kurosaki T; Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan. kurosaki@ifrec.osaka-u.ac.jp.; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. kurosaki@ifrec.osaka-u.ac.jp., Inoue T; Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan. takeshi-inoue@g.ecc.u-tokyo.ac.jp.; Department of Molecular Systems Immunology, The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan. takeshi-inoue@g.ecc.u-tokyo.ac.jp.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. takeshi-inoue@g.ecc.u-tokyo.ac.jp. |
| Source: | Nature communications [Nat Commun] 2026 Jun 26; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-74717-2 |
